GST is known as a detoxicating enzyme which catalyzes the conjugation (reaction) of various substances, which enter into an organism, or analogous substances (hereinafter referred to as substrates) which are produced in vivo, with glutathione of reduced type. Many of the substrates react with the in vivo protein or nucleic acid to cause a change to a morbid state (for instance, carcinogenesis) but the reactivity of these substrates are neutralized by said conjugation to be transformed into more water-soluble products and metabolized in the liver, etc. and finally excreted out of the body.
GST is found existing in various kinds of living species inclusive of mammals and is especially contained in considerable quantities in the liver, spleen, kidney, lung, brain, skeletal muscles, placenta, and small intestine, and also found in the skin, red blood cell, and white blood corpuscule though very small in amount. GST generally comprises various types of enzymes and is not only specific to species but also specific to the internal organs and tissues.
Glutathione S-transferase (GST) is a family of enzymes with a vital role as catalysts (a compound which aids a chemical reaction) in the detoxification of poisonous substances. The genes which code for the GST family are located on multiple chromosomes (supergenes) and variations in these genes (polymorphisms) are associated with the development of several diseases such as cancer, Parkinson’s disease, and asthma.
In terms of detoxification, when you do a coffee enema, the caffeine in the coffee enema will open up the bile duct to allow palmatic acid to produce GST enzyme up to 700%, or work up to 7 times harder in removing toxins from your body.