Aspartate is a neurotransmitter that is found in the central nervous system. Aspartate is also an amino acid, specifically the conjugate base of aspartic acid. In its capacity as a neurotransmitter, aspartate is primarily found in the spinal cord. Aspartate is an excitatory neurotransmitter.
Aspartate aminotransferase exists as two isozymes, one mitochondrial (mAspAT) and the other from the cytosol (cAspAT). Though differing markedly in primary structure, chemical and physical properties, both catalyze the same reaction with subtly different catalytic steps.
Aspartate aminotransferase (AspAT) is a key enzyme of amino acid metabolism that catalyzes the reversible transfer of the amine group from L-aspartate to 2-oxoglutarate. In mammalian tissues the enzyme is especially concentrated in heart and liver tissue. The enzyme most extensively studied is that from pig heart. The usual preparations contain only the cytosolic enzyme (cAspAT).
Aspartate aminotransferase has the highest reactivity toward L-aspartate and L-glutamate. In addition, the enzyme acts upon a number of aromatic amino acids. Non-aromatic amino acids are considerably poorer substrates.
Magnesium Aspartate is involved in over 300 enzyme systems in the body and hypomagnesemia is considered to be as prevalent as 80% in persons with long standing fatigue. Without its presence muscles may not properly relax, and spasticity occurs. Magnesium Aspartate is generally very well absorbed and tolerated by the highly sensitive individual.
Potassium Aspartate is used as a mineral transporter to the metabolizing cells, aiding in metabolic process by replenishing potassium. thereby contributing to efficient production. Potassium when associated with l-aspartic acid independently interacts with various substances in the body and participates in various physiological processes. Potassium aspartate is a safe, tolerant bioavailable delivery form of both potassium and aspartate moiety, both of which play a vital role in human nutrition in general and sports nutrition, in particular.
Blood has low levels of Aspartate Aminotransferase. If the liver or heart or any other important organ gets damaged, then more of this enzyme is expelled into the blood stream. There will be high aspartate aminotransferase in the blood, if the damage to the tissues is great. If a person has severe tissue damage, the aspartate aminotransferase levels goes up to six to ten hours, and can remain like this for about four days.